Caffeine is a stimulant that is used to stay awake and it gives mental alertness from fatigue. This is used as an adjunct for pain relief and also as energy accelerates. Caffeine is a non-prescription drug easily available as over the counter medication and comes in combination to acquire relief from headache and pain. Caffeine increases the mental alertness by offering the required energy for exercise training and weight loss. Caffeine cannot be considered as a mere stimulant as it reaches deep into muscles and provides power that is long lasting. Caffeine taken before any work out is also great as it fights the fatigue and keeps the person ready for the workout. Dieters also find caffeine as the solution as they feel sluggish. This is a no-calorie stimulant and does its job effectively and quickly. Caffeine anhydrous is found even in one or two coffee cups. However, this limitation is recommended as excess caffeine may result in irritability, rapid heart beat, nervousness and sleeplessness.

Cayenne- Most of us are aware of the wonders of the hot cayenne, which belongs to the family of capsicum. This herb is mainly used for culinary and health purpose. As compared to black pepper and chilies, it contains less irritating properties. Cayenne when taken naturally works as a natural stimulant and is beneficial for pancreas, kidney and spleen. Cayenne can be taken in herbal tea form, as a natural energy booster or as a capsule to cure yellow fever. Since cayenne contains antiseptic properties it is an effective remedy for sore throats and is used as a gargle. It aids digestion and stimulates saliva and stomach secretion. It also prevents heart attack, reduces cholesterol, allows proper absorption of vitamins, improves blood circulation and effectively clears the sinuses. In the past it was used as a cure for typhoid fever, diphtheria, pleurisy and pneumonia.

Hordenine, which is found in many grassy plants and grains. Hordenine is related to tyramine and may stimulate the release of norepinephrine to produce a stimulant effect.

PEA (Phenylethylamine) is a monoamine and alkaloid which functions as a trace amine, neurotransmitter or a neuromodulator. Phenylalanine, an amino acid, is the source from which phenethylamine, another name for PEA, is naturally biosynthesized through enzymatic decarboxylation. Compounds that are found in supplements in form of phenethylamines can be very diverse and include entactogens, anorectics, bronchodilators, hallucinogens, antidepressants and stimulants. Substituted phenethylamines are related to amphetamines, but also to dopamine, epinephrine, norepinephrine, phenylalanine and tyrosine. PEA is used by body builders and sportspeople mainly because of the stimulative effects as a neuromodulator, raising alertness, mood, concentration and focus. The additional stimulation of AMPA receptors, which boosts release of acetylcholine through the glutamatergic system, is an additional bonus of this popular supplement ingredient.