2-Methylpropionate is a vitamin-B derivative also called thiamine disulfide. It is used in medicine for treatment of asthenia (weakness, loss of appetite and inability to concentrate). It is used as supplement by bodybuilders and athletes because it is believed to increase physical resistance to fatigue, improve neuromuscular efficiency, learning and memory, and improve metabolic function of the cerebral cortex. Some users have also reported improved sleep patterns after use of 2-methylpropionate supplements. Research shows that it improves energy levels by increasing choline uptake by hippocampal neurons, thus resulting in an increase in synthesis and release of acetylcholine. Its effects on brain are because it increases neuronal membrane permeability.

Caffeine is a stimulant that is used to stay awake and it gives mental alertness from fatigue. This is used as an adjunct for pain relief and also as energy accelerates. Caffeine is a non-prescription drug easily available as over the counter medication and comes in combination to acquire relief from headache and pain. Caffeine increases the mental alertness by offering the required energy for exercise training and weight loss. Caffeine cannot be considered as a mere stimulant as it reaches deep into muscles and provides power that is long lasting. Caffeine taken before any work out is also great as it fights the fatigue and keeps the person ready for the workout. Dieters also find caffeine as the solution as they feel sluggish. This is a no-calorie stimulant and does its job effectively and quickly. Caffeine anhydrous is found even in one or two coffee cups. However, this limitation is recommended as excess caffeine may result in irritability, rapid heart beat, nervousness and sleeplessness.

Guarana Extract is the extract of the guarana plant. It contains a significant amount of guaranine, a substance that is similar to caffeine found in coffee beans. It helps stimulate the adrenal glands and increase the production and release of hormones such as epinephrine, norepinephrine (adrenaline), and dopamine. This helps the metabolism of the body that enhances fat loss, and increases energy and endurance. It helps the body burn the fats to be used for energy. It aids in fighting stress, weakness and fatigue. As a stimulant, it also improves mental alertness, clarity, focus, concentration, and memory retention. Guarana also also improves the libido or sex drive in both men and women. Guarana also contains tannins that help prevent diarrhea and soothes the digestive system.

Thiamine, also called Vitamin B1 or Thiamin, is needed to help the body utilize energy from proteins, fats and carbohydrates. Thiamine is commonly found in breads and cereals. Thiamine is water-soluble and is concentrated in muscle tissue as it passes thru the body.

Yohimbine HCL is the active chemical component of the medicinal herb Pausinystalia yohimbe. It is a stimulant drug and is reportedly an aphrodisiac. According to the National Institute of Health (NIH), the standardised form of this chemical is Yohimbine hydrochloride (HCL) and is available as a prescription drug in the United States. Research has shown that yohimbine hydrochloride is effective as a treatment for male impotence. However while yohimbine HCL has been used as a prescription medicine to treat erectile dysfunction controlled studies suggests conflicting results. Apart from male sexual dysfunction, yohimbine HCL has also been used to treat the side effects of antidepressants like female hyposexual disorder etc. It is also used to recall memories in the treatment of post-traumatic-stress-disorder. While there are several uses for yohimbine HCL, there are several side effects too. These include high blood pressure, insomnia, panic attacks, hallucinations, headaches, renal failure, heart disease etc.