Melatonin, a naturally produced chemical messenger made by the pinealocytes, the cells in the pineal gland, which is located in the brain. Melatonin is involved in the circadian cycle, where it is believed that it chemically lowers the body temperature and causes drowsiness. The pineal gland produces melatonin only when it is dark, i.e. during the night. It is furthermore believed that melatonin interacts with leptin, whereby the leptin levels are lowered. Actually it was found that the interaction with insulin stimulated the leptin levels, which seems to be responsible for appetite suppression during sleep. Further investigation provided evidence that melatonin displays strong antioxidant properties. N-Acetyl-5-Methoxytryptamine, or melatonin, has been studied extensively for treatment of many diseases, including treatment of drug abuse, cancer, seasonal affective disorder and depression.