1-Methylcaffeine occurs naturally in a few beverage and used as an agent in the pharmacological industry. It is also know as Caffeine, and is known for it stimulating effect on the nervous system. It makes a person alert and increases the level of agitation. It is used to treat certain forms of headache, stimulates the muscles of the heart, diuresis and relaxes the muscles too. 1-Methylcaffeine effect in the cells is being studied and research provides a vague insight on the pharmacological profile. Today, 1-Methylcaffeine occurs naturally and is a derivative of xanthine, similar to bronchodilator theophylline and theobromine. Availble as caffeine over the counter, it can help treat water weight gain and drowsiness. To treat headache and migraines, it is combined with ergot alkaloids or analgesics.

11-Hydroxy Yohimbine is available as extract and is reported to have toxic effects. It contains alkaloids to ten or fifteen percent. The Hydroxy Yohimbine is considered to be pure than the Herbal Yohimbine extract. Hydroxy Yohimbine extract is regarded to be safer and consistent. This is found in trees and is used as medicine to treat erectile dysfunction. Hydroxy Yohimbine is also useful in treating obesity. The common side effect is anxiety. Hence, people prone to panic attacks are recommended to avoid using Hydroxy Yohimbine. People facing disorders due to stress also should avoid Hydroxy Yohimbine. Hydroxy Yohimbine in combination with other drugs increases the nitric oxide action. For erectile dysfunction treatment Hydroxy Yohimbine should be taken 0.1 milligram/kg daily. It is best before meals, especially when the stomach is completely empty. Hydroxy Yohimbine is also a weight loss agent as it burns fat.

Alpha-Yohimbine works with potent MAOI-inhibiting properties. In this context, it basically works like an amphetamine-potentiator, as it stops the neuro-breakdown of dopamine, noradrenaline and serotonin. Having similar alpha-2 antagonistic properties to yohimbine HCI, it is also less vasoconstrictive in areas, making it less likely for inducing increase in BP. It is an analogue of yohimbine, however there is a difference in its potency at the subreceptors of alpha2, most notably at alpha2c adrenergic and alpha2b subreceptors. This is 4 times more potent alpha2c and 3 times more potent at alpha2b. Yohimbine is an alkaloid which is found in a tree’s inner bark which grows in Southern Africa. It has been in use for centuries as an aphrodisiac. Today, it is primarily used in veterinary medicines and also for the treatment of erectile dysfunction. It is also used in treating obesity.

B-Phenylethylamine HCL is a chemical which is related to the well known family of amphetamines and is thought to raise blood pressure and blood glucose levels. Since the two primary actions of Beta Phenylethylamine HCL is to raise sugar levels and the blood pressure, on taking Beta Phenylethylamine HCL one experiences a sense of well being and contentment as well as being more alert. Beta Phenylethylamine HCL also helps to focus the mood and concentration. It is also thought to be a neuromodulator and also promotes energy, elevates mood and on an upside, favours aggression. Beta Phenylethylamine HCL has also been linked with the release of b-endorphin from the brain. This is an opiod peptide which is what causes pleasurable effects. Due to this reason, Beta Phenylethylamine HCL is also known as the ‘love drug’ and since it is added to chocolate, it explains why chocolate is considered to be an aphrodisiac.

Caffeine- The bitter, white crystalline xanthine alkaloid caffeine is found in tea, coffee, soft drinks, chocolates, pain relievers, and a variety of over the counter medications. It is a psychoactive stimulant drug that causes increased alertness by stimulating the central nervous system. For the same reason, many people feel more energetic after consuming it. It even elevates the mood but these effects do not last for long. The effects of caffeine usually last for about five to six hours, though caffeine sensitivity varies from person to person. It has been found that people who consume lot of caffeine on a daily basis soon develop less sensitivity and may need to increase their intake to enjoy the same effect. Being a diuretic, a person consuming caffeine may have to urinate more often.

Methylsynephrine, also known as hydroxyephedrine, methylsympatol and oxyephedrine, is an alpha-adrenergic agonist with actions similar to that of phenylephrine. Medically, it is used as a vasoconstrictor in cases like circulatory failure, asthma, nasal congestion and glaucoma. In dietary supplements, it is a component of a weight loss pill, branded Lipo-6 Hers™. The use of this compound is to replace ephedrine, which has caused a number of controversies with regards to its side effects and adverse reactions. Along with other components like beta-phenylethylamine HCl, caffeine, folic acid and biotin, it contributes to fast, reliable and long-term weight loss. Its action exerts on the increased production of the neurotransmitters norepinephrine and dopamine for fast and dramatic weight loss. There are claims that it does not cause any “jitters” while delivering observable results. This supplement is contraindicated to pregnant and lactating women, as well as to pediatric clients. Interactions with caffeine may potentiate its effects leading to muscular tremors. This supplement is not to be taken with alcohol or alcohol-containing substances.

N-Methyl-B-Pheylethylamine HCL is a compound extracted from Acacia Rigidula. It is naturally found in chocolate. It is used in many weight loss supplements. Studies show that it produces simulation in the CNS (Central Nervous System) without giving rise to the jittery feelings or nervousness, thus enhancing metabolism, which helps to burn fat and elevate energy levels in body. Other studies also show its mental effects: N-Methyl-B-Pheylethylamine HCL is shown to increase focus, concentration and alertness of the mind. It is also shown to stimulate alpha receptors in brain that results in the release of dopamine, which gives a good feeling.

R-Beta-Methylphenylethylamine HCL is a relatively new compound which is the active isomer of Methylphenylethylamine similar to how 1R-25 Norephedrine was of PPA many years ago. What makes R-Beta-Methylphenylethylamine HCL very popular and an important component for many commercially produced weight loss products is to do with the effects it has on the human body. R-Beta-Methylphenylethylamine HCL is a compound which stimulates norepinephrine unlike any other compound in the body. By stimulating norepinehrine, R-Beta-Methylphenylethylamine HCL produces effects like appetite suppression, increase in energy and through the combination of these two effects, there is an overall result of weight loss.

Synephrine is an adrenergic amines and stimulant with beta-3 receptors. It functions to increase metabolic rate with no effect to heart rate or blood pressure. Synephrine releases adrenaline and noradrenalin in the adipose tissue and the liver. Stimulation of the beta-3 receptor sites to educe the breakdown of fat. It can be added to the group of stimulants, to which belong such supplements as caffeine or ephedrine. Can be used to boost energy, suppress appetite and enhance metabolic rate to burn more calories and increased the energy, but it does not cause so undesired negative cardiovascular effects. Its active ingredients include gelatin, cellulose, and silica and magnesium strearate. Its weight loss abilities are associated with citrus aurantium (synephrine) supplements which give it the stimulant like effects of the alkaloids.

Yohimbine HCL raises body temperatures. it increases the flow of blood to the genital area and increases the sex drive in men but also women have reported similar effects.