Bioperine is an extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper) that contains 95 percent of piperine. Black pepper is a common household spice. Extract from black pepper has also been used extensively as a medicine. To reach the greatest quality during the harvest, the pepper is reaped before ripening and after that is placed to dry under the sun rays. Bioperine is known for its effect to enhance the efficiency of many supplement nutrients. Bioperine acts to enhance the body’s natural therogenic activity – giving the name thermonutrient. This enhancement brings about increased metabolic rate creating demand for supple of many nutrients such as vitamins, minerals, herbals, amino acids. It sets in motion a process that brings about better digestion and faster gastrointestinal absorption.

Caffeine may be the most popular legal addictive stimulant that is available to mankind. Besides coffee, tea, guarana and kola nut have excess amount of this xanthine alkaloid, which is actually acting as a psychoactive drug. In several plants, caffeine is an effective insect repellant, but this trimethylxanthine is deemed by the Food and Drug Administration as generally safe food substance. It is an antagonist of adenosine receptors. The effect of caffeine is individual and may more or less increase the ability to perform physical and mental labor. It reduces the effects of fatigue and may in long term help predominantly men reduce the risk of developing Parkinson’s disease. It has also been observed that caffeine has nootropic effects, furthermore, regular consumption of caffeine may significantly reduce the risk of heart diseases.

Guggulsterone is a plant sterol found in the resin of the guggul plant, Commiphora mukul. It acts as an antagonist of the farnesoid X receptor, which was earlier believed to result in decreased cholesterol synthesis in the liver.

Synephrine is used in some products. It is also called oxedrine, and is an aromatic compound with a hydroxyl group at the para position of its benzene ring. It is derived from the fruit of Citrus aurantium, and can be taken orally or by injection. Its pharmacology is not extensively studied, but some health benefits are associated to it. It is believed to burn fat and help in weight loss. It also increases the metabolic rate and energy level. Further research might indicate more benefits of the product.

Yohimbe contains an alkaline called yohimbine. It releases a hormone that stimulates sexual organs and blood flow in the genitals known as norepinephrine. Yohimbe is known treatment for sexual dysfunctions such as male impotence. It also has aphrodisiac property that improves the libido for both men and women. Yohimbe also helps in weight loss by increasing lypolysis by enhancing the excretion of norephinephrine. It also has antioxidant properties. It may also improve and alleviate exhaustion and feebleness. Yohimbe also helps alleviate the mood by blocking the enzyme called monoamine oxidase that may cause depression. Yohimbe also causes vasodilation that helps lower blood pressure.