Caffeine is the most widely used legal stimulant of the central nervous system and is also used in Thermonex EF, with characteristics that have been described as restoration of alertness and removing from drowsiness. Coffee, Tea, many soft drinks and energy drinks as well as nutrition supplements have this ingredient, which is a psychoactive substance, a xanthine alkaloid that can act as a adenosine receptor antagonist, as well as a phosphodiesterase inhibitor. Although regular use of caffeine seems to have nootropic effects, enhancing cognitive abilities, it also is known to provide long term effects on the nervous and cardiovascular system, like in one study it was proven that people with normal to low blood pressure have the possibility of developing a heart disease significantly reduced, as well as the chance of getting the Parkinson’s disease.

Diiodotyrosine, also known as DIT, is a drug used to treat hyperthyroidism and is often included in dietary supplements designed to increase the metabolism and burn fat. It is considered a synthetic anti-thyroid agent that is used to decrease the amount of hormones the thyroid produces. In some cases it produces a response more quickly than radioactive iodine therapy while not causing the thyroid gland permanent damage. Possible serious side effects of this drug are the suppression of bone marrow which can lead the patient to having a decreased number of blood leucocytes, bronchitis, hepatitis, jaundice, skin rashes, and/or syndromes that are similar to systemic lupus erythematosus.

Evodiamine- Tetradii Fructus, the fruit of the evodia plant, also known as Tetradium rutaecarpa, contains an active element that has recently been identified as evodiamine. This chemical compound is believed to be somewhat similar to capsaicin, the active compound found in the chili peppers. Some studies suggested that this vanilloid receptor agonist may interact with thermogenin, otherwise known as the uncoupling protein 1, UCP1, which is able to generate heat by a mechanism called thermogenesis. Tetradium rutaecarpa has been traditionally used in Chinese medicine for weight loss purposes and current studies seem to verify this information. Evodiamine has been embraced as a dietary supplement directed at weight loss, predominantly by the body building circles. This supplement is deemed to have energy burning and fat reducing, as well as diuretic properties.

Green Tea Extract- For thousands of years, Green Tea has been used for the purpose of medicine in countries such as China and India. The leaves of the Camellia Sinensis plant are allowed to dry after being lightly steamed. The leaves are steamed as the properties of the plant are retained through this procedure. The extract has a number of varying health benefits, inclusive of properties that assist the body in fighting cancer and body protecting antioxidant effects. Green tea also offers protection against digestive and respiratory infections. It reduces health affecting LDL cholesterol, increases the levels of HDL cholesterol that is good for the body. Along with keeping control of the content of blood sugar in the body, it also helps burn fat in the body by boosting the metabolic rates.

Iodotyrosone, which is a form of tyrosine with iodine added.

L-Tyrosine is an amino acid taken to enhance the functions of the thyroid gland. It provides essential supplements to the body for fighting serious ailments. L-Tyrosine is a natural cure mainly for hypothyroidism and many other illnesses including protection of skin from the UV rays and depression. People suffering from hypothyroidism lack tyrosine and therefore do not respond to iodine supplements. Iodine supplements are of no use without tyrosine. Using L-tyrosine replaces vital amino acids which people having hypothyroidism lack. It produces thyroid hormones namely, norepinephrine, dopamine and epinephrine. L-tyrosine must be used by those who have a family history of under active thyroids and by those who have not got benefits from dieting efforts. L-tyrosine is taken in doses of 500mg 2 to 3 times everyday. People having high blood pressure must be cautious while taking this supplement.

Naringin is the major flavonoid glycoside in grapefruit and gives grapefruit juice its bitter taste. It occurs naturally in all citrus fruits so it is also called citrus Naringin. It is used in medicine for its pharmacological effects such as an antioxidant and for blood lipid lowering. Research also shows that Naringin can be used for inhibition of selected drug-metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2. Its anti-cancer effects are also being studied by researchers. Naringin is treated with potassium hydroxide or another strong base, and then catalytically hydrogenated to make naringin dihydrochalcone, which is used as a sugar-free sweetener 300 times sweater then sugar.

Octopamine is a biogenic substance which is containing an amine group, apparently related to noradrenaline, which is a catecholamine functioning as both, neurotransmitter and a hormone. Similar to norepinephrine, which is another name for noradrenaline, octopamine may act as a stress hormone, triggering increased heart rate, energy consumption and blood flow, even the blood pressure. One side effect of octopamine is apparently the release of fat from the adipocytes, which are the fat cells where excess energy is being stored. This side effect prompted the use of octopamine as a dietary supplement aimed at weight loss, but used in combination with other stimulants. Octopamine has been discovered in the middle of the twentieth century, but the use as a fat removal agent is very recent.

Synephrine is a drug that is deemed to selectively bind to and also activate alpha adrenergic receptors. Mainly used as a vasoconstrictor in asthma, glaucoma, circulatory failure and nasal congestion, this compound is currently propagated as a weight loss agent. The alleged function synephrine is providing include fat burning, energy level and metabolism increase and promotion of weight loss. Synephrine, also known as oxedrine, is the widely accepted replacement for ephedrine. The natural source of synephrine is the citrus aurantium fruit, better known as bitter orange. Bitter orange extracts, which contain synephrine, are known to stimulate the alpha-1 adrenergic receptor, thereby constricting blood vessels and increasing the heart rate as well as blood pressure, effecting in an increased energy use.

Yerba Matte- The plant of the yerba maté, as yerba matte is actually called, is a small tree or a shrub which can grow up to a size of fifteen meters. The leaves and twigs have traditionally been used to brew a tea like concoction, which is still a very popular social beverage in South America. Yerba maté contains alcaloids that are very similar to caffeine, commonly referred to as xanthines, but also elements like manganese, magnesium and potassium. The main difference between yerba maté and coffee, for instance, is the effect it has on muscle tissue, where it appears to relax smooth muscle tissue, but stimulate heart tissue and that is why it is used in Thermonex EF. In other studies, yerba maté was found to work as a monoamine oxidase inhibitor, thereby professing antidepressant qualities.